“Psychedelics are thought of as `mind-expanding’ drugs, so it has commonly been assumed that they work by increasing brain activity,” says Nutt. “Surprisingly, we found that psilocybin actually caused activity to decrease in areas that have the densest connections with other areas.”
— Mo Costandi quoting David Nutt, “Hallucinogenic Chemical Found in Magic Mushrooms Subdues Brain Activity”, Scientific American, 23 Jan 2012
(The article notes that Nutt’s study is contradicted by earlier studies that used slightly different methods.)